The blocks around Pioneer Courthouse Square are the heartland of upscale shopping in Portland. It's here that you'll find Nordstrom, NIKETOWN, Saks Fifth Avenue, Tiffany, Pioneer Place shopping mall, and numerous upscale boutiques and shops.
However, Portland's hippest shopping district is the Nob Hill/Northwest neighborhood along NW 23rd Avenue beginning at West Burnside Street. Here you'll find block after block of unusual boutiques as well as such chains as Gap, Urban Outfitters, and Pottery Barn.
For shops with a more down-to-earth, funky flavor, head out to the Hawthorne District, which is the city's counterculture shopping area (lots of tie-dye and imports).
In the Pearl District, of which NW Glisan Street and NW 10th Avenue are the center, you'll find the city's greatest concentration of art galleries.
Most small stores in Portland are open Monday through Saturday from 9 or 10am to 5 or 6pm. Shopping malls are usually open Monday through Friday from 9 or 10am to 9pm, on Saturday from 9 or 10am to between 6pm and 9pm, and on Sunday from 11am until 6pm. Many department stores stay open past 6pm. Most art galleries and antiques stores are closed on Monday.